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Updated: Nov 27, 2025

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
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Hepatitis C virus-associated non-Hodgkin lymphomas: the endless history

Gabriele Pozzato1, Cesare Mazzaro2, Valter Gattei2

  • 1Department of Clinical and Surgical Sciences, Maggiore Hospital, University of Trieste, Trieste, Italy - g.pozzato@fmc.units.it.

Minerva Medica
|December 2, 2020
PubMed

Insights

Hepatitis C virus (HCV) significantly contributes to non-Hodgkin's lymphoma (NHL) development. Antiviral therapies, including new direct-acting agents, show effectiveness in treating HCV-associated NHL.

Area of Science:

  • Hepatology
  • Virology
  • Oncology

Background:

  • Hepatitis C virus (HCV) infection is a global health concern with increasing recognition of extrahepatic manifestations.
  • Non-Hodgkin's lymphoma (NHL) is a significant extrahepatic complication linked to HCV infection.
  • Epidemiological data and treatment outcomes confirm HCV's role in lymphoproliferative diseases.

Purpose of the Study:

  • To review epidemiological and biological evidence linking HCV to NHL pathogenesis.
  • To discuss treatment strategies for HCV-associated NHL.

Main Methods:

  • Literature review of epidemiological studies.
  • Analysis of biological data on HCV and lymphomagenesis.
  • Review of treatment outcomes for HCV-associated NHL.

Main Results:

  • Strong epidemiological evidence supports HCV's role in NHL development.
  • Antiviral therapy, including interferon/ribavirin and direct-acting antivirals, is effective in managing HCV-associated NHL.
  • Understanding HCV's role aids in managing both hepatic and extrahepatic manifestations.

Conclusions:

  • HCV is a key factor in the pathogenesis of certain NHL types.
  • Effective antiviral treatment of HCV can lead to regression of HCV-associated NHL.
  • Further research into HCV-lymphoma interactions is warranted.

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