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Exercise and Prediabetes after Renal Transplantation (EXPRED): Protocol Description.
Raúl Morales Febles1,2, Natalia Negrín Mena2, Ana Elena Rodríguez-Rodríguez1
1Faculty of Medicine, University of La Laguna, Tenerife, Spain.
Nephron
|December 2, 2020
Summary
Exercise may reverse prediabetes in kidney transplant recipients, potentially preventing post-transplant diabetes mellitus (PTDM). This study explores exercise feasibility to guide future PTDM prevention trials.
Area of Science:
- Nephrology
- Endocrinology
- Exercise Physiology
Background:
- Post-transplant diabetes mellitus (PTDM) is a significant complication after renal transplantation, increasing risks for infection and cardiovascular disease.
- Late PTDM often develops in patients with post-transplant prediabetes, a potentially reversible condition.
- Exercise is known to prevent diabetes progression in the general population, but evidence in renal transplant patients is limited.
Purpose of the Study:
- To evaluate the feasibility of exercise interventions for reversing prediabetes in renal transplant recipients.
- To gather data for designing a future clinical trial aimed at preventing PTDM.
Main Methods:
- An exploratory analysis including renal transplant patients with prediabetes (diagnosed via fasting glucose and OGTT) more than 12 months post-transplant.
- A 12-month intervention involving progressive aerobic exercise (30-60 min/day, 5 times/week), with potential addition of anaerobic training.
- Monitoring prediabetes status (fasting glucose, OGTT) every 3 months.
Main Results:
- This section is not applicable as the abstract describes the study design and not the results.
Conclusions:
- This section is not applicable as the abstract describes the study design and not the results.
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