Related Experiment Video
Updated: Nov 27, 2025

Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis
Published on: June 19, 2018
Writing, Proofreading and Editing in Information Theory
1Instituto Madrileño de Estudios Avanzados en Nanociencia, C/Faraday 9, Cantoblanco, 28049 Madrid, Spain.
This study introduces a mathematical theory for information creation and revision, drawing inspiration from biomolecular systems. This new formalism extends thermodynamic analysis to abstract symbol strings, applicable to diverse communication systems.
Area of Science:
- Information theory
- Thermodynamics
- Biomolecular systems
Background:
- Information creation and processing lack a unified mathematical framework.
- Existing theories do not fully capture the dynamics of information generation and revision.
- Biomolecular systems offer a model for efficient information management.
Purpose of the Study:
- To develop a mathematical formalism for information creation (writing) and revision.
- To extend thermodynamic analysis of stochastic chains to abstract symbol strings.
- To provide a unified theory applicable to diverse communication systems.
Main Methods:
- Introduced 'writing' (bit string generation) and 'revision' (proofreading, editing) as core concepts.
- Developed a non-Markovian treatment for operational rules on symbol chains.
- Extended thermodynamic analysis of material chains to abstract information chains.
Main Results:
- Established a mathematical framework for information chains, analogous to material chains.
- Demonstrated how non-Markovian dynamics capture memory effects in information processing.
- Showcased the theory's applicability across various domains.
Conclusions:
- The proposed theory provides a robust mathematical foundation for understanding information.
- This formalism unifies concepts across human languages, computer science, and gene evolution.
- The physical nature of information is further elucidated through this thermodynamic approach.
Related Concept Videos
Proofreading
Proofreading
Errors During Replication are Corrected by the DNA Polymerase...
Improving Translational Accuracy
Improving Translational Accuracy
Propagation of Uncertainty from Systematic Error
Types of Errors: Detection and Minimization
Absolute error in a measurement is the numerical difference from the true or central value. Relative error is the ratio between absolute error and the true or central value, expressed as a percentage.
Errors can be classified by source, magnitude, and sign. There are three types of errors: systematic, random, and gross.
Systematic or...

