Related Experiment Video
Updated: Nov 27, 2025

Single-cell Gene Expression Profiling Using FACS and qPCR with Internal Standards
Published on: February 25, 2017
Creation of Numerical Constants in Robust Gene Expression Programming
1University of Ljubljana, Faculty of Electrical Engineering, Tržaška 25, 1000 Ljubljana, Slovenia.
Abstract:
The problem of the creation of numerical constants has haunted the Genetic Programming (GP) community for a long time and is still considered one of the principal open research issues. Many problems tackled by GP include finding mathematical formulas, which often contain numerical constants. It is, however, a great challenge for GP to create highly accurate constants as their values are normally continuous, while GP is intrinsically suited for combinatorial optimization. The prevailing attempts to resolve this issue either employ separate real-valued local optimizers or special numeric mutations. While the former yield better accuracy than the latter, they add to implementation complexity and significantly increase computational cost. In this paper, we propose a special numeric crossover operator for use with Robust Gene Expression Programming (RGEP). RGEP is a type of genotype/phenotype evolutionary algorithm closely related to GP, but employing linear chromosomes. Using normalized least squares error as a fitness measure, we show that the proposed operator is significantly better in finding highly accurate solutions than the existing numeric mutation operators on several symbolic regression problems. Another two important advantages of the proposed operator are that it is extremely simple to implement, and it comes at no additional computational cost. The latter is true because the operator is integrated into an existing crossover operator and does not call for an additional cost function evaluation.
More Related Videos
12:54Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
Published on: March 7, 2018
07:03Determining Genome-wide Transcript Decay Rates in Proliferating and Quiescent Human Fibroblasts
Published on: January 2, 2018
Related Concept Videos
Numerical Calculations
The solution to a problem is obtained using different methods. While manually solving algebraic symbols is one of the most common methods, the graphical method is often preferred. Computers...
Regulation of Expression at Multiple Steps
Real Time RT-PCR
The real-time quantification of the number of amplified products is...
Combinatorial Gene Control
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
Constitutive and Regulated Gene Expression
Cell Specific Gene Expression