Related Experiment Video
Updated: Nov 27, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
Published on: July 17, 2020
PP2A-B55 Holoenzyme Regulation and Cancer
Perrine Goguet-Rubio1, Priya Amin1, Sushil Awal1
1Centre de Recherche en Biologie Cellulaire de Montpellier (CRBM), Université de Montpellier, Équipe Labellisée "Ligue Nationale Contre le Cancer", CNRS UMR 5237, 1919 Route de Mende, CEDEX 5, 34293 Montpellier, France.
Abstract:
Protein phosphorylation is a post-translational modification essential for the control of the activity of most enzymes in the cell. This protein modification results from a fine-tuned balance between kinases and phosphatases. PP2A is one of the major serine/threonine phosphatases that is involved in the control of a myriad of different signaling cascades. This enzyme, often misregulated in cancer, is considered a tumor suppressor. In this review, we will focus on PP2A-B55, a particular holoenzyme of the family of the PP2A phosphatases whose specific role in cancer development and progression has only recently been highlighted. The discovery of the Greatwall (Gwl)/Arpp19-ENSA cascade, a new pathway specifically controlling PP2A-B55 activity, has been shown to be frequently altered in cancer. Herein, we will review the current knowledge about the mechanisms controlling the formation and the regulation of the activity of this phosphatase and its misregulation in cancer.
More Related Videos
Related Concept Videos
Abnormal Proliferation
Negative Regulator Molecules
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Epigenetic Regulation
X-chromosome...

