Related Experiment Video
Updated: Nov 27, 2025
07:54
Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
20.3K
Obstructive Sleep Apnea and Incident Cancer: A Large Retrospective Multicenter Clinical Cohort Study
Tetyana Kendzerska1,2,3, Marcus Povitz4,5, Richard S Leung6,7
1Department of Medicine, The Ottawa Hospital/University of Ottawa, Ottawa, Ontario, Canada. tkendzerska@toh.ca.
Summary
Severe obstructive sleep apnea (OSA) and low nocturnal oxygen levels independently increase cancer risk. This highlights the need for increased cancer awareness in individuals diagnosed with OSA.
Area of Science:
- Sleep Medicine
- Oncology
- Epidemiology
Background:
- Obstructive sleep apnea (OSA) is a common sleep disorder.
- Nocturnal hypoxemia, a consequence of OSA, involves reduced blood oxygen during sleep.
- The relationship between OSA severity, hypoxemia, and cancer incidence requires further investigation.
Purpose of the Study:
- To investigate the association between obstructive sleep apnea (OSA) severity and nocturnal hypoxemia with the risk of developing incident cancer.
Main Methods:
- A multicenter retrospective cohort study analyzed linked clinical and administrative data from adults undergoing sleep studies.
- Cancer status was tracked using the Ontario Cancer Registry.
- Cox regressions calculated cancer risk, absolute risk difference (ARD), and number needed to harm (NNH).
Main Results:
- Severe OSA (apnea-hypopnea index >30) was associated with a 15% increased hazard of incident cancer (HR=1.15).
- Severe nocturnal hypoxemia (sleep time with SpO2 <90% >30%) was linked to a 30% increased cancer hazard (HR=1.32).
- Both OSA severity and hypoxemia showed independent associations with cancer development.
Conclusions:
- In individuals suspected of OSA and free of cancer at baseline, OSA severity and nocturnal hypoxemia are independently associated with incident cancer.
- Findings suggest a need for targeted cancer risk awareness in OSA patients.
More Related Videos
Related Concept Videos
01:21Sleep Apnea
330
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
330
01:17Other Pulmonary Disorders
1.3K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.3K
01:11Observational Studies
10.5K
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
10.5K
01:21Cancer Survival Analysis
535
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
535
01:25Statistical Methods for Analyzing Epidemiological Data
740
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
740
02:59Cancer Prevention
7.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.3K