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The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
Published on: November 30, 2016
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[Cachexia and Sarcopenia Associated with Lung Cancer].
Satomi Tanaka1, Koichi Takayama
1Dept. of Pulmonary Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medical Science.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|December 3, 2020
Summary
Lung cancer is a leading cause of cancer death in Japan. New treatments like Anamorelin and the NEXTAC program show promise for managing cancer cachexia, a severe complication.
Area of Science:
- Oncology
- Gastroenterology
- Geriatrics
Background:
- Lung cancer is the leading cause of cancer mortality in Japan, with a low 5-year survival rate for advanced stages.
- Cancer cachexia affects approximately 70% of advanced lung cancer patients at diagnosis, contributing to treatment resistance and mortality.
- Current treatments for cancer cachexia are limited, necessitating the development of effective multimodal strategies.
Purpose of the Study:
- To explore Anamorelin, a ghrelin receptor agonist, for its potential in treating cancer cachexia.
- To evaluate the feasibility and safety of the Nutrition and Exercise Treatment for Advanced Cancer (NEXTAC) program.
- To investigate novel therapeutic approaches for managing cancer cachexia in advanced cancer patients.
Main Methods:
- Anamorelin's efficacy in improving lean body mass in patients with advanced non-small cell lung cancer (NSCLC) and gastrointestinal cancer with cachexia was assessed.
- The NEXTAC program, a multimodal intervention, was implemented in elderly patients with advanced NSCLC and pancreatic cancer.
- Feasibility and safety of the NEXTAC program were evaluated in the target patient population.
Main Results:
- Anamorelin demonstrated promising results in improving lean body mass in patients with advanced cancer and cachexia.
- The NEXTAC program exhibited excellent feasibility and safety in elderly patients with advanced NSCLC and pancreatic cancer.
- These findings suggest potential for novel interventions in cancer cachexia management.
Conclusions:
- Anamorelin shows potential as a therapeutic agent for cancer cachexia, particularly in improving lean body mass.
- The NEXTAC program is a feasible and safe multimodal intervention for elderly patients with advanced cancer and cachexia.
- Further research and development of multimodal treatments are crucial for effectively managing cancer cachexia.
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