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Effect of Original Peptide Derivatives of Galantamine on Passive Avoidance in Mice
I I Kostadinova1, N D Danchev2, L T Vezenkov3
1Department of Pharmacology, Pharmacotherapy, and Toxicology, Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria. i.kostadinova@pharmfac.musofia.bg.
Bulletin of Experimental Biology and Medicine
|December 3, 2020
Abstract:
The effect of original peptide derivatives of galantamine on scopolamine-induced memory impairment in mice was assessed using the passive avoidance test over 12 days. It was found that some galantamine derivatives administered in a dose of 1/20LD50 improved the memory in experimental mice, especially on days 5-12 of the experiment.
Keywords:
Alzheimer’s diseasegalantaminepassive avoidancepeptide derivatives of galantaminescopolamine
