Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Disorders of Hemostasis

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

Introduction to Hemostasis

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...

Venous Thrombosis I: Introduction

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...

Vascular Spasm

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neonatal Survival After Serial Amnioinfusions for Anhydramnios Due to Fetal Kidney Failure: The RAFT Clinical Trial.

JAMA·2026

Same author

Does early gastrostomy tube placement after stroke improve functional recovery and quality of life? A literature-informed pathway-decomposition analysis.

Neurological research·2026

Same author

Corticospinal tract risk modifies motor recovery after minimally invasive surgery for intracerebral hemorrhage: a secondary analysis of MISTIE-III.

medRxiv : the preprint server for health sciences·2026

Same author

Circulating Short-Chain Fatty Acid Profile Predicts Functional Outcome After Moderate-to-Severe Traumatic Brain Injury.

Critical care explorations·2026

Same author

Conducting multicenter trials through the trial innovation network comprehensive consultation.

Contemporary clinical trials·2026

Same author

Hematoma Interleukin-1 Receptor Antagonist Concentrations Predict Long-Term Outcome in Acute Human Intracerebral Hemorrhage.

Annals of neurology·2026

Same journal

Preface.

Handbook of clinical neurology·2026

Same journal

Foreword.

Handbook of clinical neurology·2026

Same journal

Fundus autofluorescence imaging.

Handbook of clinical neurology·2026

Same journal

The electroretinogram as a means to study the physiology of the retina.

Handbook of clinical neurology·2026

Same journal

Adaptive optics scanning light ophthalmoscopy.

Handbook of clinical neurology·2026

Same journal

Modeling the human retina in a dish: Advances and future directions.

Handbook of clinical neurology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 27, 2025

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

Hemorrhagic stroke.

Arturo Montaño¹, Daniel F Hanley², J Claude Hemphill³

¹Departments of Neurology and Neurosurgery, University of Colorado, Aurora, CO, United States.

Handbook of Clinical Neurology

|December 4, 2020

Summary

This summary is machine-generated.

Intracerebral hemorrhage (ICH) is a severe stroke type. Current guidelines focus on blood pressure control, reversing anticoagulants, and surgery for cerebellar bleeds, with ongoing research into optimal treatments.

Keywords:

Blood pressure Coagulopathy reversal Hematoma Intracerebral hemorrhage Intraventricular hemorrhage Minimally invasive surgery

More Related Videos

A Murine Model of Subarachnoid Hemorrhage

A Murine Model of Subarachnoid Hemorrhage

Published on: November 21, 2013

Using Zebrafish Larvae to Study the Pathological Consequences of Hemorrhagic Stroke

Using Zebrafish Larvae to Study the Pathological Consequences of Hemorrhagic Stroke

Published on: June 5, 2019

Related Experiment Videos

Last Updated: Nov 27, 2025

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

A Murine Model of Subarachnoid Hemorrhage

A Murine Model of Subarachnoid Hemorrhage

Published on: November 21, 2013

Using Zebrafish Larvae to Study the Pathological Consequences of Hemorrhagic Stroke

Using Zebrafish Larvae to Study the Pathological Consequences of Hemorrhagic Stroke

Published on: June 5, 2019

Area of Science:

Neurology
Neurosurgery
Vascular Medicine

Background:

Hemorrhagic stroke, particularly intracerebral hemorrhage (ICH), accounts for 20% of all strokes.
ICH carries a high risk of mortality and long-term disability, exacerbated by untreated hypertension.
Limited randomized controlled trials (RCTs) have historically hindered evidence-based interventions for ICH.

Purpose of the Study:

To review current evidence-based guidelines and emerging research for managing intracerebral hemorrhage (ICH).
To discuss established and evolving treatment strategies for acute blood pressure management, coagulopathy reversal, and surgical interventions in ICH.
To highlight areas of ongoing clinical research and address the management of cerebral venous thrombosis as a subtype of hemorrhagic stroke.

Main Methods:

Review of existing evidence-based guidelines for intracerebral hemorrhage (ICH) management.
Analysis of current clinical practices including acute blood pressure control, coagulopathy reversal, and surgical evacuation.
Discussion of findings from recent and ongoing randomized controlled trials (RCTs) and clinical research.

Main Results:

Current ICH management emphasizes controlling severe hypertension, rapid reversal of vitamin K antagonists, and surgical evacuation of cerebellar hemorrhages.
Significant research gaps remain regarding optimal blood pressure targets, reversal of novel anticoagulants, and the efficacy of minimally invasive surgery.
Risk stratification models exist but should be used cautiously to avoid limiting treatment based on presumed poor prognosis.

Conclusions:

Evidence-based guidelines provide a framework for ICH care, focusing on acute interventions.
Ongoing research is crucial for refining treatment strategies and addressing remaining clinical questions in ICH management.
Cerebral venous thrombosis represents a distinct subtype of hemorrhagic stroke requiring specific diagnostic and therapeutic approaches.