Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clonidine.

H Roehrich1, M S Gold

  • 1Fair Oaks Hospital, Summit, NJ 07901.

Advances in Alcohol & Substance Abuse
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

Clonidine, an alpha-2 adrenergic agonist, offers a nonaddictive treatment for opiate withdrawal. This breakthrough has spurred research into its use for various neuropsychiatric conditions, expanding treatment options.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mandibular condylar process remodeling in rats with different bite-altering devices.

European cells & materials·2023
Same author

Consumer acceptability and validity of m-Health for the detection of adverse events following immunization - The Stimulated Telephone Assisted Rapid Safety Surveillance (STARSS) randomised control trial.

Vaccine·2020
Same author

Efficacy of m-Health for the detection of adverse events following immunization - The stimulated telephone assisted rapid safety surveillance (STARSS) randomised control trial.

Vaccine·2020
Same author

Recovery of brain structural abnormalities in morbidly obese patients after bariatric surgery.

International journal of obesity (2005)·2016
Same author

Inflammatory mediator-induced modulation of GABAA currents in human sensory neurons.

Neuroscience·2015
Same author

Elevated IL-5 and IL-13 responses to egg proteins predate the introduction of egg in solid foods in infants with eczema.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2015
Same journal

Drug dependence: defining the issues.

Advances in alcohol & substance abuse·1990
Same journal

Reactions of methadone patients to HIV antibody testing.

Advances in alcohol & substance abuse·1990
Same journal

Smoking behavior in nine year old children: a replication and extension study.

Advances in alcohol & substance abuse·1990
Same journal

Relationship between morbidity and mortality due to alcoholic cardiomyopathy and alcohol consumption in Australia.

Advances in alcohol & substance abuse·1990
Same journal

Alcohol consumption and pain phobia: toward a unifying theory of alcoholism.

Advances in alcohol & substance abuse·1990
Same journal

The diagnosis of alcohol and cannabis dependence in cocaine dependence.

Advances in alcohol & substance abuse·1990
See all related articles

Area of Science:

  • Pharmacology
  • Neuroscience
  • Addiction Medicine

Background:

  • Opiate withdrawal presents a significant clinical challenge, historically lacking nonaddictive treatment options.
  • Clonidine, an alpha-2 adrenergic agonist, was identified as a potential solution for managing opiate withdrawal symptoms.
  • Preclinical research laid the groundwork for investigating clonidine's efficacy in addiction treatment.

Purpose of the Study:

  • To evaluate clonidine as a nonaddictive agent for opiate detoxification.
  • To explore the broader utility of clonidine in treating various neuropsychiatric disorders.
  • To investigate novel, non-addictive therapeutic strategies for opiate dependency.

Main Methods:

  • Initial clinical trials demonstrated clonidine's effectiveness in detoxifying opiate addicts.

Related Experiment Videos

  • Subsequent research involved studies across a range of conditions including neonatal narcotic addiction and alcohol detoxification.
  • Further investigations explored its application in conditions such as akathisia, mania, and attention deficit disorder.

    • Main Results:

    • Clonidine proved to be a nonaddictive alternative for treating opiate withdrawal.
    • The drug showed potential in managing symptoms associated with alcohol detoxification.
    • Research indicated clonidine's applicability to a spectrum of neuropsychiatric conditions.

    Conclusions:

    • Clonidine represents a significant advancement in providing nonaddictive opiate withdrawal management.
    • The drug's efficacy extends to other neuropsychiatric conditions, broadening its therapeutic scope.
    • Further research continues to explore clonidine's potential for non-addictive addiction treatment.