YAP Triggers Bladder Cancer Proliferation by Affecting the MAPK Pathway
Dandan Qiu1, Yan Zhu1, Zhicheng Cong2
1Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People's Republic of China.
Cancer Management and Research
|December 4, 2020
Summary
The transcriptional regulator YAP is overexpressed in bladder cancer, promoting cell proliferation and migration. YAP acts as an oncogene, making it a potential therapeutic target for bladder cancer treatment.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- The transcriptional regulator YAP is often overexpressed in various human cancers, including breast and pancreatic cancers.
- YAP plays a significant role in tumorigenesis and influences multiple factors critical for cancer progression.
Purpose of the Study:
- To investigate the specific effects of YAP expression on the development and progression of bladder cancer.
- To determine YAP's role as a potential therapeutic target in bladder cancer.
Main Methods:
- Assessed changes in cellular functions (proliferation, migration, cell cycle, apoptosis) following YAP knockdown or overexpression in bladder cancer cell lines.
- Utilized Western blot analysis to confirm protein level alterations induced by YAP modulation.
Main Results:
- YAP expression was found to be higher in bladder cancer tissues compared to normal tissues.
- YAP knockdown inhibited, while YAP overexpression promoted, bladder cancer cell proliferation and migration.
- Overexpression of YAP was associated with increased activity of the MAPK/ERK signaling pathway.
Conclusions:
- Established YAP as an oncogene contributing to bladder cancer progression.
- Identified YAP as a potential therapeutic target for bladder cancer treatment.
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