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Updated: Nov 27, 2025
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Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
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[Organ changes found by postmortem examination in COVID-19 patients]
A A Odilov1, N S Tsimbalist1, A V Volkov1,2
1Peoples' Friendship University of Russia, Moscow, Russia.
Arkhiv Patologii
|December 4, 2020
Summary
Postmortem analysis of 186 COVID-19 patients reveals significant lung pathology, including congestion and diffuse alveolar damage. Kidney damage, such as acute tubular necrosis, was also consistently observed across studies.
Area of Science:
- Pathology
- Pulmonology
- Nephrology
Background:
- COVID-19 causes significant multi-organ pathology.
- Postmortem studies are crucial for understanding disease progression and effects.
Purpose of the Study:
- To analyze and synthesize postmortem findings in COVID-19 patients.
- To detail pathological changes in the respiratory, circulatory, and excretory systems.
Main Methods:
- Systematic review and analysis of 20 literature sources.
- Examination of postmortem data from 186 COVID-19 patients.
Main Results:
- Lung pathology included increased weight, congestion, compaction, and diffuse alveolar damage (DAD) with alveolocyte proliferation and hyaline membranes.
- Kidney pathology consistently showed acute tubular necrosis, tubular dilatation, and interstitial edema.
- Significant thrombosis and pulmonary embolism were noted in 22% of cases, linked to deep vein thrombosis.
Conclusions:
- COVID-19 induces severe multi-organ damage, particularly affecting the lungs and kidneys.
- Postmortem findings highlight the systemic impact of SARS-CoV-2 infection, including thrombotic events.
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