Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

5.4K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
5.4K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

209
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
209
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

8.0K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.0K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

475
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
475
The Parathyroid Glands00:59

The Parathyroid Glands

3.9K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
3.9K
The Bone Matrix01:18

The Bone Matrix

5.2K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Directional bone matrix mineralization in the CAM assay is governed by vascular integration and matrix remodeling.

bioRxiv : the preprint server for biology·2026
Same author

Surface Reconstruction in Hydrated Amphiphilic Block Copolymer Thin Films Probed by Fluid Cell Atomic Force Microscopy.

Macromolecules·2026
Same author

Uncovering the Subtleties of Solvation and Speciation of Organic Halide Salts in Organic Solvents.

The journal of physical chemistry. B·2026
Same author

Recapitulating Native-Like Strain Distributions in a Tissue-Engineered Enthesis by Creating Structural, Biochemical, and Mineral Gradients.

Journal of biomedical materials research. Part A·2025
Same author

Calcium Oxalate Crystals with a Bipyramidal Morphology and a High Tendency to Aggregate Attach Directly to Breast Cancer Cells and Affect Their Phenotype.

ACS applied materials & interfaces·2025
Same author

siRNA Treatment Enhances Collagen Fiber Formation in Tissue-Engineered Meniscus via Transient Inhibition of Aggrecan Production.

Bioengineering (Basel, Switzerland)·2025
Same journal

Diabetic Wound Healing Enabled by a Tri-Functional MAX Phase via Cu Doping.

Advanced healthcare materials·2026
Same journal

Plasmonically Reinforced Self-Sufficient Nanozymes Dysregulating Redox Homeostasis for Augmented Cascade Catalytic Oncotherapy.

Advanced healthcare materials·2026
Same journal

Spontaneous Helical Alignment of Smooth Muscle Cells to Form a Medial Layer for Engineered Microvasculature.

Advanced healthcare materials·2026
Same journal

Injectable Antifouling Adhesive Hydrogel Enables Robust Neural Interfaces for Stable ECoG Recording.

Advanced healthcare materials·2026
Same journal

Bioactive Electrode System With External Connectivity for Electrically Augmented Bone Regeneration.

Advanced healthcare materials·2026
Same journal

Tailoring Drug Release Profiles From Electrospun Alginate Fibers Through Integration of Mesoporous Silica Nanoparticles.

Advanced healthcare materials·2026
See all related articles

Related Experiment Video

Updated: Nov 27, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

20.0K

Multiple Pathways for Pathological Calcification in the Human Body.

Netta Vidavsky1, Jennie A M R Kunitake2, Lara A Estroff2,3

  • 1Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, 8410501, Israel.

Advanced Healthcare Materials
|December 4, 2020
PubMed
Summary
This summary is machine-generated.

Physiological mineralization is tightly controlled by cells. Pathological calcification, however, can occur due to disease or biomaterials, impacting health and requiring advanced study for diagnosis and treatment.

Keywords:
apatitebiomineralizationbreast cancer microcalcificationscardiovascular calcificationspsammoma bodies

More Related Videos

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.2K
Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models
09:01

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

1.9K

Related Experiment Videos

Last Updated: Nov 27, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

20.0K
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.2K
Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models
09:01

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

1.9K

Area of Science:

  • Biomineralization research
  • Pathological calcification mechanisms
  • Materials science in medicine

Background:

  • Skeletal biomineralization (bone, teeth) involves cellular regulation for functional composites.
  • Pathological mineralization can arise from disease, metabolic issues, or biomaterials, posing health risks.
  • Understanding cellular control differences is key to distinguishing physiological and pathological pathways.

Purpose of the Study:

  • Define mineralization pathway components.
  • Identify commonalities and differences between physiological and pathological calcification.
  • Explore pathological mineralization in cancer and cardiovascular disease.

Main Methods:

  • Comparative analysis of mineralization pathways.
  • Review of calcium phosphate-based pathological mineralization.
  • Emphasis on advanced materials science imaging and characterization techniques.

Main Results:

  • Distinguishes physiological and pathological mineralization based on cellular control extent.
  • Highlights calcium phosphate involvement in cancers (breast, thyroid, ovarian, meningioma) and cardiovascular disease.
  • Stresses the need to study nucleation, growth, and aggregation stages.

Conclusions:

  • Mechanistic insights into pathological mineralization are crucial.
  • Advanced characterization techniques are vital for understanding early stages.
  • Understanding pathological calcification can aid diagnosis, prognosis, and treatment development.