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An infant with localized vasoconstriction following topical propranolol exposure for infantile hemangioma

Julie Saerens1, Jan Gutermuth1, Sherief R Janmohamed1

  • 1Department of Dermatology, University Hospital Brussels (UZ Brussel, UZB), Vrije Universiteit Brussel (VUB), Jette, Belgium.

Pediatric Dermatology
|December 4, 2020
PubMed

Insights

Topical propranolol for infantile hemangioma can cause temporary blanched skin patches due to vasoconstriction. Proper application instructions are crucial to prevent this reversible side effect.

Area of Science:

  • Dermatology
  • Pediatrics
  • Pharmacology

Background:

  • Infantile hemangiomas are common vascular tumors in infants.
  • Topical propranolol is an emerging treatment for superficial infantile hemangiomas.
  • Understanding potential side effects of topical propranolol is essential for safe and effective use.

Observation:

  • A 3-month-old infant developed blanched macules on the forehead after topical propranolol treatment for an infantile hemangioma.
  • The blanched macules appeared at the site of propranolol application.

Findings:

  • Topical non-selective beta-blockers, like propranolol, can cause peripheral vasoconstriction.
  • This vasoconstriction leads to the observed blanched macules, a potential side effect of topical propranolol.
  • The side effect was associated with overuse and was reversible upon appropriate management.

Implications:

  • This case highlights the importance of precise application techniques and dosage instructions for topical propranolol.
  • Healthcare providers should educate caregivers about potential side effects and proper usage.
  • Further research may explore optimal dosing and application methods to minimize adverse events.

Keywords:
beta-blockerdrug reactioninfantile hemangiomapropranololtimolol

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