Lexicon Knowledge Boosted Interaction Graph Network for Adverse Drug Reaction Recognition From Social Media

The World Health Organization underlines the significance of adverse drug reaction (ADR) reports for patients' safety. Actually, many potential ADRs tend to be under-reported in post-market ADR surveillance. Recognizing ADRs from social media is indispensably important and could complement post-market ADR surveillance for more effective pharmacovigilance studies. However, previous approaches pose two challenges: 1) ADRs show high expression variability in social media, and thus, many potential ADRs are out-of-lexicon ones, which are difficult to be recognized, and 2) most phrasal ADRs are non-standard mentions and their boundaries are difficult to identify accurately. To tackle these challenges, we design three interaction graphs and propose a neural network approach, i.e., Interaction Graph Network (IGN). Specifically, to recognize more out-of-lexicon ADRs, besides the mentions in ADR lexicon, noun phrases in the input sentence are regarded as candidate phrases and their features are taken into considerations. Moreover, in an attempt to accurately identify ADR boundaries, three word-phrase interaction graphs are designed to represent lexicon knowledge and are encoded using graph attention networks (GATs) to directly integrate various boundary and contextual information of candidate phrases into ADR recognition. Experimental results on two benchmark datasets show that IGN can recognize ADR accurately and consistently outperforms other state-of-the-art approaches.