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Comparison of the clinical manifestations between different age groups of patients with overseas imported COVID-19

Yujuan Han1, Zujin Luo2, Wenliang Zhai3

  • 1Department of Internal Medicine, Beijing Xiaotangshan Hospital, Beijing, China.

Plos One
|December 4, 2020
PubMed

Insights

Older patients with imported COVID-19, especially those with type 2 diabetes, experienced more severe lung disease and complications. This highlights the need for increased clinical attention for this vulnerable demographic.

Area of Science:

  • Infectious Diseases
  • Pulmonology
  • Geriatrics

Background:

  • COVID-19 has a significant global health impact.
  • Understanding age-related clinical differences in COVID-19 is crucial for patient management.
  • Overseas imported cases present unique epidemiological characteristics.

Purpose of the Study:

  • To investigate the clinical manifestations and outcomes of COVID-19 in different age groups among overseas imported cases.
  • To compare disease progression, complications, and treatment responses between younger and older COVID-19 patients.

Main Methods:

  • Retrospective analysis of 53 overseas imported COVID-19 patients admitted to Beijing Xiaotangshan Hospital.
  • Patients categorized into two groups: ≤40 years (Group A) and >40 years (Group B).
  • Comparison of demographic data, clinical symptoms, chest CT findings, lab indices, and treatment outcomes.

Main Results:

  • Older patients (Group B) showed a higher proportion of common COVID-19 type and type 2 diabetes comorbidity.
  • Group B exhibited more frequent CT abnormalities, including multiple lesions and bilateral lung involvement.
  • Older patients had a greater proportion of disease aggravation during hospitalization and a higher incidence of adverse drug reactions.

Conclusions:

  • Older imported COVID-19 patients, particularly those with type 2 diabetes, face a higher risk of severe disease and complications.
  • Age is a significant factor influencing COVID-19 severity and progression.
  • Clinical practice should prioritize increased attention and tailored management for older COVID-19 patients.

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