The moderating role of sensory processing sensitivity in the link between stress and depression: A VBM study

This study examined whether components of sensory processing sensitivity (SPS) could moderate the effect of perceived stress on depressive symptoms and its neural substrates. In this study, 244 participants (181females) reported on their SPS, perceived stress, and experienced depressive symptoms, and subsequently underwent a resting-state functional magnetic resonance imaging (RS-fMRI) to explore the neural basis of their SPS characteristics. Behavioral results showed that, compared with individuals low in EOE (i.e., ease of excitation, a sub-dimension of SPS), those high in EOE were more likely to report depressive symptoms under stress. The VBM analysis indicated that EOE was significantly positively correlated with gray matter (GM) volumes of right cerebellum and negatively correlated with GM volumes of right dorsal anterior cingulate cortex (right dACC). Moreover, GM volumes of the two areas moderated the relation between stress and depression. These findings collectively suggest that the structural abnormalities in these regions might account for simulating and experiencing intense emotional reactions frequently among individuals with high EOE. Thus, the accumulation of these negative emotions in reaction to stress may lead to higher probabilities of experiencing depressive symptoms. Taken together, present study shed light on how stress interacted with sensory processing sensitivity to predict depression from the neural perspective.