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Related Concept Videos

The Blood-brain Barrier

The Blood-brain Barrier

Physiological Barriers

Physiological Barriers

Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...

Factors Affecting Drug Distribution: Physiological Barriers

Factors Affecting Drug Distribution: Physiological Barriers

Drug distribution in the body is intricately regulated by various physiological barriers that control the passage of substances. These include the capillary endothelial barrier, the blood-brain, blood-cerebrospinal fluid, blood-placental, and blood-testis barriers.
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...

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Related Experiment Video

Updated: Nov 27, 2025

Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics

Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics

Published on: November 30, 2012

Breaking down the blood-brain barrier

Naveed Wagle¹, Santosh Kesari¹

¹Pacific Neuroscience Institute and John Wayne Cancer Institute at Providence St John's Health Center, Santa Monica, California.

|December 5, 2020

Summary

No abstract available in PubMed .

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