Terra firma-forme dermatosis: a systematic review

Area of Science:

• Dermatology
• Clinical Medicine

Background:

• Terra firma-forme dermatosis (TFFD) is an acquired pigmentation disorder with debated etiology and pathogenesis.
• Clinical presentation varies from brownish patches to hyperkeratotic plaques.
• A lack of critical data analysis hinders understanding of TFFD.

Purpose of the Study:

• To provide a key point-summary of Terra firma-forme dermatosis (TFFD).
• To review clinical outcomes, comorbidities, pathogenesis, histopathology, dermoscopy, and therapeutic options for TFFD.

Main Methods:

• A comprehensive literature search was conducted in PubMed and Google Scholar.
• Identified and screened 102 published papers reporting clinical cases of TFFD.
• Reviewed records of 256 patients meeting inclusion criteria.

Main Results:

• Terra firma-forme dermatosis (TFFD) presents with a mean patient age of 18.34 years.
• A significant female predominance was observed, with a female:male ratio of 1:37.
• The condition characteristically regresses upon application of 70% isopropyl alcohol.

Conclusions:

• This review consolidates current knowledge on Terra firma-forme dermatosis (TFFD).
• It highlights the diagnostic and therapeutic implications of isopropyl alcohol treatment.
• Further research is needed to clarify the pathogenesis and associations of TFFD.