Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

6.6K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical outcome and predictive factors for docetaxel and epirubicin neoadjuvant chemotherapy of locally advanced breast cancer.

The Korean journal of internal medicine·2020
Same author

Hypofractionated Radiation Therapy for Progressive Heterotopic Ossification: The Relationship between Dose and Efficacy.

International journal of radiation oncology, biology, physics·2020
Same author

Deep learning-based interpretation of basal/acetazolamide brain perfusion SPECT leveraging unstructured reading reports.

European journal of nuclear medicine and molecular imaging·2020
Same author

Cognitive signature of brain FDG PET based on deep learning: domain transfer from Alzheimer's disease to Parkinson's disease.

European journal of nuclear medicine and molecular imaging·2019
Same author

Clinical implication of 18F-NaF PET/computed tomography indexes of aortic calcification in coronary artery disease patients: correlations with cardiovascular risk factors.

Nuclear medicine communications·2019
Same author

Amyloid PET Quantification Via End-to-End Training of a Deep Learning.

Nuclear medicine and molecular imaging·2019

Related Experiment Video

Updated: Nov 27, 2025

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

10.6K

Spatial Normalization Using Early-Phase [18F]FP-CIT PET for Quantification of Striatal Dopamine Transporter Binding.

Sungwoo Bae1,2, Hongyoon Choi1,3, Wonseok Whi1,2

  • 1Department of Nuclear Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080 Republic of Korea.

Nuclear Medicine and Molecular Imaging
|December 7, 2020
PubMed
Summary

An early-phase dopamine transporter (DAT) PET scan offers accurate spatial normalization for parkinsonism assessment when MRI is unavailable. This method improves putaminal binding ratio quantification compared to delayed-phase scans.

Keywords:
Dopamine transporter imagingEarly-phase imageQuantitative analysisSpatial normalization[18F]FP-CIT PET

More Related Videos

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
15:10

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat

Published on: December 28, 2013

7.2K
Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level
07:28

Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level

Published on: January 24, 2025

565

Related Experiment Videos

Last Updated: Nov 27, 2025

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

10.6K
A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
15:10

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat

Published on: December 28, 2013

7.2K
Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level
07:28

Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level

Published on: January 24, 2025

565

Area of Science:

  • Nuclear medicine and molecular imaging
  • Neuroscience and neurology
  • Medical physics and image analysis

Background:

  • Accurate quantification of dopamine transporter (DAT) density using [18F]FP-CIT PET is essential for assessing striatal DAT loss in parkinsonism.
  • Quantitative analysis relies on spatial normalization to a template brain, a process that can be limited by delayed-phase PET imaging.
  • Magnetic Resonance Imaging (MRI) serves as a gold standard for anatomical normalization in PET imaging.

Purpose of the Study:

  • To develop and evaluate an early-phase [18F]FP-CIT PET-based spatial normalization method for quantifying striatal DAT density.
  • To compare the accuracy of early-phase PET normalization against a delayed-phase PET method and an MRI-based approach.
  • To assess the utility of early-phase PET normalization when MRI is not available for patients with parkinsonism.

Main Methods:

  • Retrospective analysis of 39 patients with parkinsonism who underwent dual-phase [18F]FP-CIT PET and MRI.
  • Application of three spatial normalization techniques: MRI-based, delayed PET template-based, and early PET template-based.
  • Comparison of striatal binding ratios (BRs) using Bland-Altman plots, intraclass correlation coefficients, and voxelwise paired t-tests.

Main Results:

  • Early-phase PET-based normalization demonstrated concordant putaminal [18F]FP-CIT binding patterns with the MRI-based method.
  • Higher agreement in putamen BRs was observed between the MRI-based and early image-based methods (ICC=0.980) compared to the delayed method (ICC=0.895).
  • Voxelwise analysis revealed a smaller volume of significant differences in putamen counts between early image and MRI normalization versus delayed image and MRI.

Conclusions:

  • Early-phase [18F]FP-CIT PET imaging provides a reliable method for spatial normalization, especially when MRI is unavailable.
  • The early-phase PET-based method offers superior performance in quantifying the putaminal binding ratio compared to the delayed template-based method.
  • This approach enhances the accuracy of DAT quantification in patients with parkinsonism, aiding in the assessment of neurodegeneration.