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Updated: Nov 27, 2025

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Relative retinal flow velocity detection using optical coherence tomography angiography imaging.

Dmitry Richter^1,2,3, Ali M Fard¹, Jochen Straub¹

¹Carl Zeiss Meditec, Inc., Dublin, CA 94568, USA.

Biomedical Optics Express

|December 7, 2020

Summary

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This summary is machine-generated.

This study introduces a new method to measure retinal blood flow velocity using optical coherence tomography angiography (OCTA). This technique enhances OCTA

Area of Science:

Ophthalmology
Medical Imaging
Biomedical Engineering

Background:

Optical coherence tomography angiography (OCTA) provides detailed retinal vasculature visualization.
Conventional OCTA protocols have limitations in dynamic range and velocity-intensity correlation due to long scan intervals.
Distinguishing between fast and slow retinal blood flow is crucial for diagnosing early-stage retinal diseases like vein occlusion.

Purpose of the Study:

To develop and validate a method for detecting relative blood flow velocity in the human retina using spectral-domain OCTA.
To overcome the limitations of conventional OCTA in assessing flow dynamics.
To enhance the diagnostic capabilities of OCTA for retinal vascular conditions.

Main Methods:

Utilized a 67.5 kHz spectral-domain OCTA device.

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Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

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Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

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Adapted A-scan time-intervals within a single OCTA acquisition to expand the detectable velocity range.

Combined resulting OCTA images and validated the method with microchannel flow experiments.

Main Results:

Successfully demonstrated a method to detect relative flow velocity in the human retina.
Expanded the detectable velocity range of OCTA by modifying scan acquisition parameters.
Validated the quantitative accuracy of the method through controlled flow experiments.

Conclusions:

The developed OCTA method enables the detection of relative retinal blood flow velocity.
This approach improves the dynamic range and velocity correlation of OCTA imaging.
The technique shows promise for the early assessment of retinal diseases by analyzing blood flow dynamics.