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The cardiac complications of COVID-19: many publications, multiple uncertainties

Abdallah Al-Mohammad1,2, David G Partridge2,3, Graham Fent2

  • 1Department of Infection, Immunity and Cardiovascular Diseases, University of Sheffield, Sheffield, UK.

Vascular Biology (Bristol, England)
|December 7, 2020
PubMed

Insights

This review examines cardiac complications of COVID-19, a novel respiratory illness. While cardiovascular issues are noted, their direct incidence and causality in COVID-19 patients remain uncertain.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • COVID-19 (Coronavirus Disease 2019) has rapidly generated extensive research.
  • Physicians face challenges assimilating vast information on this novel disease.
  • COVID-19, primarily respiratory, is linked to cardiovascular complications.

Purpose of the Study:

  • To critically review and appraise existing data on cardiac complications associated with COVID-19.
  • To present case examples from clinical experience.
  • To identify knowledge gaps and uncertainties in this evolving field.

Main Methods:

  • Systematic literature review and critical appraisal of published data.
  • Analysis of reported cardiovascular complications in COVID-19 patients.
  • Case study presentation.

Main Results:

  • COVID-19 is associated with various cardiovascular complications.
  • The precise incidence of direct cardiac involvement in COVID-19 is not yet clearly established.
  • Reported complications can occur in patients without COVID-19, complicating direct attribution.

Conclusions:

  • Further research is needed to clarify the direct role of COVID-19 in cardiac complications.
  • Understanding the cardiovascular impact of COVID-19 is crucial for patient management.
  • Significant uncertainties remain regarding the long-term cardiovascular sequelae of COVID-19.

Keywords:
COVID-19infectioninflammationmicrovasculaturemyocardial injurythrombosisvascular disease

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