Severe cortical damage associated with COVID-19 case report.

Area of Science:

• Neurology
• Infectious Diseases
• Genetics

Background:

• The 2019-2020 SARS-CoV-2 pandemic primarily presented with respiratory and gastrointestinal symptoms.
• Neurological manifestations of COVID-19 were infrequently reported during the initial pandemic phase.
• Cornelia de Lange syndrome is a rare genetic disorder affecting multiple body systems.

Observation:

• A 17-year-old female with Cornelia de Lange syndrome and controlled epilepsy presented with a severe condition.
• The patient experienced a COVID-19 associated multi-inflammatory syndrome.
• Significant cortical injury was observed in the patient.

Findings:

• The case details a severe neurological complication in a pediatric patient with a pre-existing genetic condition.
• Cortical injury occurred in the context of a multi-inflammatory syndrome linked to SARS-CoV-2 infection.
• This presentation underscores the potential for severe neurological sequelae in specific patient populations.

Implications:

• Highlights the need for vigilance regarding neurological complications in COVID-19, particularly in vulnerable individuals.
• Suggests that patients with genetic syndromes may be at increased risk for severe COVID-19 related neurological damage.
• Emphasizes the importance of comprehensive patient monitoring during and after SARS-CoV-2 infection.