Related Experiment Video
Updated: Nov 27, 2025
Pupillometry to Assess Auditory Sensation in Guinea Pigs
Published on: January 6, 2023
Target detection in healthy 4-week old piglets from a passive two-tone auditory oddball paradigm
R Anna Oeur1, Susan S Margulies2,3
1Wallace H. Coulter Department of Biomedical Engineering, Emory University, 615 Michael St. Suite 655, Atlanta, GA, USA.
Background:
Passive auditory oddball tests are effort independent assessments that evaluate auditory processing and are suitable for paediatric patient groups. Our goal was to develop a two-tone auditory oddball test protocol and use this clinical assessment in an immature large animal model. Event-related potentials captured middle latency P1, N1, and P2 responses in 4-week old (N = 16, female) piglets using a custom piglet 32- electrode array on 3 non-consecutive days. The effect of target tone frequency (250 Hz and 4000 Hz) on middle latency responses were tested in a subset of animals.
Results:
Results show that infrequent target tone pulses elicit greater N1 amplitudes than frequent standard tone pulses. There was no effect of day. Electrodes covering the front of the head tend to elicit greater waveform responses. P2 amplitudes increased for higher frequency target tones (4000 Hz) than the regular 1000 Hz target tones (p < 0.05).
Conclusions:
Two-tone auditory oddball tests produced consistent responses day-to-day. This clinical assessment was successful in the immature large animal model.
