Related Experiment Video
Updated: Nov 26, 2025

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
Published on: June 21, 2024
What is the ideal combination antiemetic regimen?
Alberto A Uribe1, Sergio D Bergese2
1Department of Anesthesiology, Wexner Medical Center, The Ohio State University College of Medicine, Columbus, OH, USA.
A combination of serotonin 5-HT3 receptor antagonists and dexamethasone is the safest and most effective approach for preventing postoperative nausea and vomiting (PONV). This multimodal strategy addresses PONV
Area of Science:
- Anesthesiology and Pharmacology
- Surgical Patient Care
Background:
- Postoperative nausea and vomiting (PONV) and post-discharge nausea and vomiting (PDNV) are common adverse events following surgery.
- PONV and PDNV can lead to complications and delayed hospital discharge.
- The optimal prophylactic regimen for PONV remains undetermined despite extensive research.
Purpose of the Study:
- To evaluate the effectiveness of different antiemetic drug classes in managing PONV.
- To identify the safest and most effective combination regimen for PONV prophylaxis.
Main Methods:
- Review of over 1000 clinical controlled trials evaluating various antiemetic drugs.
- Analysis of randomized clinical trials (RCTs) focusing on combination regimens.
- Comparison of drug classes including 5-hydroxytryptamine (5-HT3) receptor antagonists, dopamine receptor antagonists, and corticosteroids.
Main Results:
- 5-HT3 receptor antagonists are frequently used for PONV prophylaxis.
- Multimodal approaches using drugs with different mechanisms are recommended for patients with risk factors.
- Combinations of 5-HT3 receptor antagonists with dexamethasone or droperidol are most studied in RCTs.
Conclusions:
- A multimodal approach is essential for managing the complex etiology of PONV.
- The combination of serotonin 5-HT3 receptor antagonists with dexamethasone appears to be the safest and most effective regimen for PONV prevention.
More Related Videos
05:33Author Spotlight: Alleviating Nausea and Vomiting in Pregnancy with Safe and Effective Auricular Acupuncture
Published on: August 4, 2023
15:04Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
Prevention of Further Absorption of Poison
Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists
Drug Dosage Regimen: Overview
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...