Related Experiment Video
Updated: Nov 26, 2025

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
Continuous increases of surface ozone and associated premature mortality growth in China during 2015-2019
Kamal Jyoti Maji1, Anil Namdeo1
1Air Quality Research Group, Department of Geography and Environmental Sciences, Northumbria University, Newcastle Upon Tyne, NE1 8ST, United Kingdom.
Abstract:
Ambient ozone (O3) pollution has become a big issue in China. Recent studies have linked long- and short-term O3 exposure to several public health risks. In this study, we (1) characterize the long-term and short-term O3-attributed health metric in China from 2015 to 2019; (2) estimate the surface O3 trends; and (3) quantify the long-term and short-term health impacts (i.e. all-cause, cardiovascular and respiratory mortality) in 350 urban Chinese cities. In these 5-years, the national annual average of daily maximum 8 h average (AVGDMA8) O3 concentrations and warm-season (April-September) 4th highest daily maximum 8 h average (4DMA8) O3 concentrations increased from 74.0 ± 15.5 μg/m3 (mean ± standard deviation) to 82.3 ± 12.0 μg/m3 and 167 ± 37.0 μg/m3 to 174 ± 30.0 μg/m3 respectively. During this period, the DMA8 O3 concentration increased by 1.9 ± 3.3 μg/m3/yr across China, with over 70% of the monitoring sites showing a positive upward trend and 19.4% with trends >5 μg/m3/yr. The estimated long-term all-cause, cardiovascular and respiratory premature mortalities attributable to AVGDMA8 O3 exposure in 350 Chinese cities were 181,000 (95% CI: 91,500-352,000), 112,000 (95% CI: 38,100-214,000) and 33,800 (95% CI: 0-71,400) in 2019, showing increases of 52.5%, 52.9% and 54.6% respectively compared to 2015 levels. Similarly, short-term all-cause, cardiovascular and respiratory premature mortalities attributed to ambient 4DMA8 O3 exposure were 156,000 (95% CI: 85,300-227,000), 73,500 (95% CI: 27,500-119,000) and 28,600 (95% CI: 14,500-42,800) in 2019, increases of 19.6%, 19.8% and 21.2% respectively compared to 2015. The results of this study are important in ascertaining the effectiveness of recent emission control measures and to identify the areas that require urgent attention.
Related Concept Videos
Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Global Climate Change
Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Other Pulmonary Disorders
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

