The study and application of biomolecules in deep eutectic solvents

Area of Science:

• Biochemistry and Biotechnology
• Green Chemistry
• Materials Science

Background:

• Biomolecules are crucial in various applications, historically studied in diverse solvents.
• Ionic liquids, while explored as alternatives to organic solvents, present limitations in cost, convenience, and sustainability.
• Deep eutectic solvents (DES) are emerging as promising alternatives due to their biodegradability, low toxicity, and cost-effective, solventless preparation.

Purpose of the Study:

• To review recent advancements and insights into biomolecular behavior within DES.
• To highlight the utility and potential of DES in various biopharmaceutical and biotechnological applications.
• To assess the environmental and economic advantages of DES compared to traditional solvents.

Main Methods:

• Literature review of recent research on DES and biomolecular interactions.
• Analysis of studies demonstrating DES applications in biostabilization, biocatalysis, and separations.
• Evaluation of DES properties for drug delivery and biomass treatment.

Main Results:

• DES demonstrate significant advantages in biostabilization of proteins and nucleic acids.
• DES show promise in enzyme and whole-cell biocatalysis, extraction processes, and drug solubilization.
• DES are effective in lignocellulose biomass treatment and targeted drug delivery systems.

Conclusions:

• Deep eutectic solvents offer a sustainable and versatile platform for diverse biomolecular applications.
• DES present a viable alternative to conventional solvents, meeting environmental responsibility requirements.
• The unique properties of DES unlock new possibilities in biomedical, biotechnological, and industrial ventures.