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Related Experiment Video

Updated: Nov 26, 2025

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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TRPM Channels in Human Diseases.

Ivanka Jimenez1,2, Yolanda Prado1,2, Felipe Marchant1,2

  • 1Faculty of Life Science, Universidad AndrĂ©s Bello, Santiago 8370186, Chile.

Cells
|December 9, 2020
PubMed
Summary
This summary is machine-generated.

Transient Receptor Potential Melastatin (TRPM) channels are crucial ion channels. Dysregulation of TRPM channels is linked to various human diseases, making them key targets for new therapies.

Keywords:
TRPM channelshuman diseasesion channels

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Area of Science:

  • Molecular Biology
  • Ion Channel Physiology
  • Human Pathophysiology

Background:

  • The Transient Receptor Potential Melastatin (TRPM) subfamily comprises eight members of the TRP cation channel family.
  • These members form homomeric or heteromeric channels, structurally classified into four groups based on C-terminal homology.

Purpose of the Study:

  • To review the main characteristics of all TRPM family members.
  • To focus on the roles of TRPM channels in human diseases.

Main Methods:

  • Literature review of TRPM channel research.
  • Analysis of structural classifications and functional roles.

Main Results:

  • TRPM channels are implicated in numerous physiological functions.
  • Alterations in TRPM channel expression and function are associated with cardiovascular diseases, neurodegeneration, organ dysfunction, and cancer.

Conclusions:

  • TRPM channels play significant roles in human health and disease.
  • TRPM channels represent promising targets for novel diagnostic and therapeutic strategies.