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Establishment of A Mouse Model of Aqueous Deficiency Dry Eye
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Defining Dry Eye from a Clinical Perspective.

Kazuo Tsubota1, Stephen C Pflugfelder2, Zuguo Liu3

  • 1Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan.

International Journal of Molecular Sciences
|December 9, 2020
PubMed
Summary
This summary is machine-generated.

A new clinical consensus defines dry eye disease (DED) as a multifactorial condition involving an unstable tear film (TF), causing discomfort and visual issues. This definition aids consistent diagnosis and research for dry eye patients globally.

Keywords:
corneal epitheliopathydefinitiondry eyedry eye signsdry eye symptomsinflammationneuropathic paintear film breakup

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Area of Science:

  • Ophthalmology
  • Ocular Surface Disease

Background:

  • Dry eye disease (DED) incidence is rising globally, with higher rates in Asia, suggesting potential cultural or racial factors.
  • Existing definitions of DED vary, leading to diagnostic inconsistencies worldwide.

Purpose of the Study:

  • To establish a unified, clinical consensus definition for dry eye disease (DED).
  • To provide a practical definition for consistent diagnosis and to guide future research and clinical trials.

Main Methods:

  • Convened four meetings with global experts in dry eye disease (DED).
  • Developed a consensus definition based on expert discussions and clinical insights.

Main Results:

  • Proposed definition: Dry eye is a multifactorial disease with an unstable tear film (TF), causing discomfort/visual impairment, and potentially involving ocular surface epitheliopathy, inflammation, and neurosensory abnormalities.
  • Key diagnostic criteria include unstable TF, inflammation, ocular discomfort, and visual impairment.
  • Recommends assessing ocular surface epitheliopathy and neurosensory abnormalities in suspected DED cases.

Conclusions:

  • The new consensus definition is clinically applicable and promotes consistent DED diagnosis.
  • This standardized definition aims to overcome previous research and clinical trial limitations caused by a lack of surrogate endpoints.