Evidence-Based Research in Nursing Science: A Reproducible Framework
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Updated: Nov 26, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
1Graduate Researcher, College of Nursing, The Pennsylvania State University, University Park, PA, USA.
Abstract:
While current clinical research generally employs complex computational methods to analyze large amounts of data, reproducible research is a growing movement within the scientific community. This methodology paper consists of five sections discussing the definitions of replicability, reproducibility, and reproducible research, the current status of reproducible research in nursing science, the introduction of a reproducible framework, and the challenges and recommendations for reproducible research. To ensure the data preprocessing process and data analysis of an original study at the minimum standard, it is necessary for the study's data investigative cycle to be transparent. Most arguments for reproducible research were driven by a critical review of journal articles and conference proceedings. The suggested methodological framework capturing how scientific research generates is expected to contribute to guiding nurse scientists to conduct reproducible research. To generate high-quality scientific evidence for evidence-based practice, the reproducible framework should be integrated into nursing research.
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