Related Experiment Video

Updated: Nov 26, 2025

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
08:56

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

11.2K

N6-methyladenine modification in noncoding RNAs and its function in cancer

Xinyu Yang1,2, Xiang Hu1,2, Jinting Liu1,2

  • 1Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, P.R. China.

Biomarker Research
|December 9, 2020
PubMed

Insights

Non-coding RNAs (ncRNAs) and N6-methyladenosine (m6A) modification are crucial in cancer. Their interplay regulates gene expression, offering potential as cancer biomarkers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Oncology

Background:

  • Non-coding RNAs (ncRNAs) are key regulators of biological processes.
  • N6-methyladenosine (m6A) modification is a prevalent RNA modification impacting RNA metabolism.
  • Dysregulation of ncRNAs and m6A is implicated in cancer progression.

Purpose of the Study:

  • To review the regulatory mechanisms between m6A methylation and ncRNAs.
  • To highlight the impact of the m6A-ncRNA interaction on cancer biology.
  • To explore their potential as prognostic markers and therapeutic targets in cancer.

Main Methods:

  • Literature review of recent research on m6A modification and ncRNAs in cancer.
  • Analysis of regulatory pathways involving m6A and ncRNAs.
  • Synthesis of findings on their roles in tumor gene expression and cancer development.

Main Results:

  • m6A modification extensively influences ncRNA function and stability.
  • The interaction between m6A and ncRNAs plays a pivotal role in cancer development.
  • Specific ncRNAs are regulated by m6A, affecting oncogenic or tumor-suppressive pathways.

Conclusions:

  • The interplay between m6A and ncRNAs offers novel insights into cancer gene regulation.
  • m6A modification and ncRNAs represent promising prognostic biomarkers for various cancers.
  • Targeting the m6A-ncRNA axis presents a potential therapeutic strategy for cancer treatment.
Keywords:
CancerNoncoding RNAsm6A modification

More Related Videos

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry08:45

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry

Published on: April 21, 2022

2.6K
Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis08:50

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis

Published on: May 14, 2020

7.0K

Related Concept Videos

RNA Editing02:23

RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.5K
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.0K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.3K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.4K
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
32.7K
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.5K