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Corrected Version: Protection of Mice from Controlled Cortical Impact Injury by Food Additive Glyceryl Tribenzoate.

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Corrected Version: Sodium Benzoate, A Metabolite of Cinnamon and A Food Additive, Improves Cognitive Functions in Mice After Controlled Cortical Impact Injury.

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Benzoate Drugs for Traumatic Brain Injury.

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RETRACTED: Rangasamy et al. Protection of Mice from Controlled Cortical Impact Injury by Food Additive Glyceryl Tribenzoate. <i>Int. J. Mol. Sci.</i> 2023, <i>24</i>, 2083.

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Can cinnamon spice down autoimmune diseases?

Swarupa Pahan1, Kalipada Pahan1,2

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Cinnamon and its metabolite, sodium benzoate, show potential in modulating autoimmune pathways. Research suggests these natural compounds may help manage autoimmune disorders by influencing immune cells and inflammation.

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Area of Science:

  • Immunology
  • Pharmacology
  • Natural Products Research

Background:

  • Autoimmune diseases are complex, with pathogenesis not fully understood.
  • Key factors include decreased T regulatory cells (Treg) and increased autoreactive Th1/Th17 cells, leading to immunomodulation and inflammation.

Purpose of the Study:

  • To review evidence on cinnamon and sodium benzoate (NaB) in modulating autoimmune pathways.
  • To analyze potential anti-autoimmune mechanisms of these compounds.
  • To assess the feasibility of using cinnamon supplements for autoimmune disorder management.

Main Methods:

  • Literature review of studies investigating cinnamon (Cinnamomum verum/cassia) and its metabolite sodium benzoate (NaB).
  • Analysis of reported effects on immune cell populations (Treg, Th1/Th17) and inflammatory markers.
  • Examination of evidence from animal models of autoimmune disorders.

Main Results:

  • Cinnamon and NaB have demonstrated the ability to modulate various autoimmune pathways.
  • These compounds have shown protective effects in animal models of autoimmune diseases.
  • Evidence suggests interference with key inflammatory and immune dysregulation processes.

Conclusions:

  • Cinnamon and NaB exhibit promising immunomodulatory and anti-autoimmune properties.
  • Further research is warranted to explore their therapeutic potential in human autoimmune diseases.
  • Cinnamon supplements may represent a viable complementary approach for managing autoimmune conditions.