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Can cinnamon spice down autoimmune diseases?

Swarupa Pahan1, Kalipada Pahan1,2

  • 1Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, USA.

Journal of Clinical & Experimental Immunology
|December 9, 2020
PubMed

Insights

Cinnamon and its metabolite, sodium benzoate, show potential in modulating autoimmune pathways. Research suggests these natural compounds may help manage autoimmune disorders by influencing immune cells and inflammation.

Area of Science:

  • Immunology
  • Pharmacology
  • Natural Products Research

Background:

  • Autoimmune diseases are complex, with pathogenesis not fully understood.
  • Key factors include decreased T regulatory cells (Treg) and increased autoreactive Th1/Th17 cells, leading to immunomodulation and inflammation.

Purpose of the Study:

  • To review evidence on cinnamon and sodium benzoate (NaB) in modulating autoimmune pathways.
  • To analyze potential anti-autoimmune mechanisms of these compounds.
  • To assess the feasibility of using cinnamon supplements for autoimmune disorder management.

Main Methods:

  • Literature review of studies investigating cinnamon (Cinnamomum verum/cassia) and its metabolite sodium benzoate (NaB).
  • Analysis of reported effects on immune cell populations (Treg, Th1/Th17) and inflammatory markers.
  • Examination of evidence from animal models of autoimmune disorders.

Main Results:

  • Cinnamon and NaB have demonstrated the ability to modulate various autoimmune pathways.
  • These compounds have shown protective effects in animal models of autoimmune diseases.
  • Evidence suggests interference with key inflammatory and immune dysregulation processes.

Conclusions:

  • Cinnamon and NaB exhibit promising immunomodulatory and anti-autoimmune properties.
  • Further research is warranted to explore their therapeutic potential in human autoimmune diseases.
  • Cinnamon supplements may represent a viable complementary approach for managing autoimmune conditions.

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