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Adsorption of immunologically relevant molecules--its present and future
1Department of Internal Medicine of the Wilhelm-Pieck-University, Rostock, GDR.
Biomaterials, Artificial Cells, and Artificial Organs
|January 1, 1987
Summary
Defining terms for adsorbents is crucial. Specific adsorbents, or immunoadsorbents, mimic antigen-antibody binding, while other selective adsorbents target specific molecules like IgG, IgE, and IgM.
Area of Science:
- Biomaterials Science
- Immunology
- Analytical Chemistry
Background:
- Numerous adsorbents exist, necessitating clear terminology for their function and application.
- Adsorbents can be classified based on their binding mechanisms, distinguishing specific interactions from selective ones.
Purpose of the Study:
- To define and differentiate terms related to adsorbents, particularly specific adsorbents (immunoadsorbents) and selective adsorbents.
- To review current research on selective adsorbents for various applications.
- To highlight the potential of blocking the complement system for improved biocompatibility.
Main Methods:
- Review of existing literature on adsorbent classification and function.
- Analysis of studies investigating selective adsorbents for antibody removal.
- Examination of synthetic materials with immunoglobulin-binding properties.
Main Results:
- Adsorbents utilizing antigen-antibody binding principles should be termed specific adsorbents or immunoadsorbents.
- Protein A-type adsorbents are effective for removing immunoglobulin G (IgG) antibodies.
- Development is ongoing for synthetic materials capable of binding immunoglobulin E (IgE) and immunoglobulin M (IgM).
Conclusions:
- Clear terminology is essential for understanding adsorbent mechanisms and applications.
- Selective adsorbents show promise for targeted removal of specific antibodies.
- Modulating the complement system via adsorbent interactions can enhance biomaterial biocompatibility.