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Updated: Nov 26, 2025

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Isocyanide Insertion-Cyclization Reaction for Imidazoisoindol-5-imine Scaffold Synthesis: A Selective Solvatochromic
Fereshteh Ahmadi1,2, Hamid Reza Goli1, Yaser Balmohammadi1
1Department of Chemistry, Shahid Beheshti University, G.C., Tehran 1983963113, Iran.
Abstract:
An efficient, ligand-free, and Pd-catalyzed method for the synthesis of imidazoisoindole imine scaffolds with satisfactory yields via C-C and C-N bond formation has been developed. The synthesized scaffolds have unique potential for selective MeOH detection from other solvents, especially EtOH. The appealing features of this transformation are phosphinic ligand-free conditions, the use of a small amount of Pd(OAc)2, and a practical procedure for the synthesis of imidazoisoindole imine scaffolds.
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