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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
Recent Insights into Emerging Coronavirus: SARS-CoV-2.
Zifang Shang1, Siew Yin Chan1, William J Liu2
1Frontiers Science Center for Flexible Electronics (FSCFE), Xian Institute of Flexible Electronics (IFE) & Xi'an Institute of Biomedical Materials and Engineering (IBME), Northwestern Polytechnical University (NPU), Xi'an 710072, China.
This review covers the source, transmission, and pathology of SARS-CoV-2 (the virus causing COVID-19). It also details diagnostic methods and treatments, including clinical trials for vaccines and therapies.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic, originating in late 2019, has caused millions of infections and deaths globally.
- Significant public health measures have been implemented worldwide to control the spread and impact of the virus.
Purpose of the Study:
- To provide a comprehensive review of the current knowledge regarding the origin, transmission dynamics, and pathogenesis of SARS-CoV-2.
- To summarize recent advancements in diagnostic techniques and therapeutic strategies for coronavirus disease 2019 (COVID-19).
Main Methods:
- Literature review and synthesis of existing research on SARS-CoV-2.
- Analysis of data from ongoing clinical trials for COVID-19 interventions.
Main Results:
- Detailed understanding of SARS-CoV-2 source, transmission routes, and mechanisms of disease.
- Overview of emerging diagnostic tools and therapeutic approaches, including antibody treatments, vaccines, and antiviral inhibitors.
Conclusions:
- The review consolidates critical information on SARS-CoV-2, aiding in the understanding and management of the COVID-19 pandemic.
- Highlights the importance of ongoing research and clinical trials in developing effective countermeasures against the novel coronavirus.
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