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Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
Published on: June 11, 2011
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Microbiome of the Middle Meatus in HIV
J Lawal1, A S Labaran1, A Ibrahim2
1National Ear Care Centre, Kaduna, Nigeria.
West African Journal of Medicine
|December 9, 2020
Summary
Human Immunodeficiency Virus (HIV) patients have a higher prevalence of bacteria in their sinonasal passages compared to HIV-negative individuals. This study investigated the sinonasal microbiome in HIV patients without rhinosinusitis.
Area of Science:
- Microbiology
- Immunology
- Otolaryngology
Background:
- Human Immunodeficiency Virus (HIV) infection causes immune dysfunction, increasing susceptibility to infections.
- The sinonasal microbiome's role in HIV-associated rhinosinusitis is not well understood.
- Investigating the sinonasal microbiome in HIV patients is crucial for understanding potential health risks.
Purpose of the Study:
- To identify bacterial species present in the middle meatus of HIV-infected adults without rhinosinusitis.
- To compare the sinonasal microbiome of HIV-infected individuals with that of HIV-negative controls.
Main Methods:
- Endoscopic middle meatal swabs were collected from 141 HIV-infected patients and 141 HIV-negative controls.
- Specimens underwent microscopy and bacterial culture.
- Statistical analysis was performed to compare bacterial isolates between groups.
Main Results:
- Bacteria were isolated from 48.9% of HIV-infected patients and 29.8% of controls.
- Common isolates included Staphylococcus epidermidis, Staphylococcus aureus, Streptococcus, Bacteroides, and Peptostreptococcus.
- A statistically significant difference in bacterial isolates was observed between HIV-infected and HIV-negative individuals (P=0.001).
Conclusions:
- The bacterial species found in HIV-infected individuals were similar to those in controls.
- HIV-infected individuals exhibited a higher overall number of bacterial isolates in their sinonasal passages.
- These findings suggest alterations in the sinonasal microbiome composition in HIV infection.
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