Related Experiment Video
Updated: Nov 26, 2025

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
Published on: May 22, 2013
[Longevity clocks: The promoting role of telomeres?]
Julien Cherfils-Vicini1, Éric Gilson2
1Université Côte-d'Azur, Inserm, CNRS, Institut de recherche sur le cancer et le vieillissement (Institute for Research on Cancer and Aging, Nice IRCAN), FHU OncoAge, 28 avenue Valombrose, Nice, France.
Abstract:
Aging is an alteration of our physiological capacities that is accompanied by an increased susceptibility to develop a wide range of diseases and which determines in large part our longevity. Despite intensive research on the origin of aging, its etiology is still poorly understood. We discuss here the hypothesis that the telomere shortening, programmed to start at the end of embryogenesis in numerous tissues, couples development with aging by a time-dependent regulation of a set of interconnected processes essential for the somatic maintenance of genome, epigenome, metabolism, circadian clock and immunity.
More Related Videos
08:34Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Published on: April 13, 2015
10:39A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
Related Concept Videos
Telomeres and Telomerase
Telomeres and Telomerase
Replication in Eukaryotes
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes
Replicative Cell Senescence
Circadian Rhythms and Gene Regulation