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[Let's be more ambitious in treating suicide].

Philippe Courtet1, Bénédicte Nobile1, Émilie Olié1

  • 1Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Univ Montpellier, Inserm, CHU de Montpellier, Montpellier, France. - Département d'urgence et de post-urgence psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France.

Medecine Sciences : M/S
|December 9, 2020
PubMed
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Suicidal behavior (SB) is a significant public health issue. Research into its underlying mechanisms, like psychological pain, may lead to new treatments, with ketamine showing promise.

Area of Science:

  • Public health
  • Psychiatry
  • Neuroscience

Background:

  • Suicidal behavior (SB) is a major public health concern requiring identification of at-risk individuals.
  • The DSM-5's classification of SB as a distinct disease aids in understanding its unique pathophysiology.
  • Currently, no specific treatments exist for SB, which has historically been viewed as a symptom of other psychiatric disorders.

Purpose of the Study:

  • To explore the role of psychological pain in the pathophysiology of suicidal behavior.
  • To identify potential new therapeutic avenues for suicidal behavior.

Main Methods:

  • Review of current literature on suicidal behavior (SB) and psychological pain.
  • Analysis of emerging research on the neurobiological underpinnings of SB.

Related Experiment Videos

  • Evaluation of preliminary data on novel therapeutics for SB.

    • Main Results:

    • Psychological pain is increasingly recognized as a key factor in understanding SB.
    • Emerging research suggests novel mechanisms underlying SB.
    • Ketamine has demonstrated promising preliminary results in treating SB.

    Conclusions:

    • Understanding psychological pain is crucial for deciphering SB pathophysiology.
    • New therapeutic strategies for SB are emerging.
    • Ketamine represents a potential novel treatment for suicidal behavior.