Related Experiment Video
Updated: Nov 26, 2025

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
Published on: February 29, 2020
Barriers to timely tympanostomy tube placement in trisomy 21
Kevin Bachrach1, Ashank Bains1, Jennifer N Shehan2
1Boston University School of Medicine, 72 E Concord Street, Boston, MA 02118, USA.
Insights
Children with trisomy 21 (Down syndrome) face longer waits for tympanostomy tube insertion compared to the general population. This delay in ear tube surgery may stem from the higher prevalence of other health issues in children with Down syndrome.
Area of Science:
- Pediatrics
- Genetics
- Otolaryngology
Background:
- Trisomy 21, or Down syndrome, is a common genetic disorder associated with increased risks of chronic ear disease.
- Children with Down syndrome often have complex medical needs that can impact healthcare access and timely treatment.
- Understanding care disparities for medical interventions like tympanostomy tube insertion is crucial for this population.
Purpose of the Study:
- To investigate potential delays in tympanostomy tube insertion for children with trisomy 21.
- To identify factors contributing to any observed delays in surgical care for this group.
Main Methods:
- Retrospective analysis of electronic medical records at Boston Medical Center (2005-2019).
- Comparison of patients with trisomy 21 undergoing tympanostomy tube insertion against a matched cohort without trisomy 21.
- Primary outcome measured: time from surgical decision to tympanostomy tube insertion.
Main Results:
- A cohort of 20 patients with trisomy 21 was matched with 39 patients from the general population.
- The average time to tympanostomy tube insertion was significantly longer for children with trisomy 21 (119.0 days) compared to the general population (43.1 days).
- The difference in wait times was statistically significant (p < .01).
Conclusions:
- Children with trisomy 21 experience significant delays in receiving tympanostomy tube insertion.
- These delays may be attributed to the greater burden of comorbid conditions common in individuals with trisomy 21.
- Addressing these delays is important for managing chronic ear disease in children with Down syndrome.
Objectives:
Trisomy 21 is the most common chromosomal abnormality in the United States with an incidence of 1 in 700 in live-born children. Children with trisomy 21 are at increased risk for chronic ear disease, as well as other medical issues that may complicate healthcare access. In this study, we investigate whether children with trisomy 21 experience delays in tympanostomy tube insertion, and if there are any factors that contribute to a delay in care.
Methods:
We performed a retrospective analysis on patients with trisomy 21 undergoing tympanostomy tube insertion at Boston Medical Center between 2005 and 2019 by analyzing the electronic medical record. This cohort was matched to patients without trisomy 21 by age, gender, surgery date and surgeon. The primary outcome was time elapsed between surgery decision date and date of tympanostomy tube insertion.
Results:
A total of 20 patients with trisomy 21 underwent tympanostomy tube insertion at Boston Medical Center between 2005 and 2019. The trisomy 21 cohort was matched to 39 patients in the general population. The average time elapsed from decision to undergo surgery to tympanostomy tube insertion was 43.1 days in the general population and 119.0 days in the trisomy 21 cohort (p < .01).
Conclusion:
Patients with trisomy 21 experience greater delays in tympanostomy tube insertion than the general population, which may be due to the increased burden of comorbid conditions in people with trisomy 21.
Related Concept Videos
Tracheostomy: Procedure and Tubes
Tracheostomy tubes can be made of semiflexible plastic (polyurethane or silicone), rigid plastic, or metal, and they come in...
Oxygen Delivering System III: Tracheostomy and T-piece
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
Tracheostomy Care I: Pre-procedural Steps
Required Equipment
The equipment necessary for tracheostomy care includes:
Tracheostomy Decannulation
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
Endotracheal Intubation I: Procedure
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...

