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Updated: Nov 26, 2025

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
Published on: October 28, 2019
Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV
Maria Anele Romeo1,2, Roberta Santarelli1,2, Maria Saveria Gilardini Montani1,2
1Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Abstract:
Human Herpes Virus-6 (HHV-6), Epstein-Barr Virus (EBV) and Kaposi Sarcoma Herpes Virus (KSHV) are viruses that share with other member of the Herpesvirus family the capacity to interfere with the autophagic process. In this paper, mainly based on the findings of our laboratory, we describe how, through different mechanisms, these viruses converge in reducing autophagy to impair DC immune function and how, by infecting and dysregulating autophagy in different cell types, they promote the pathologies associated with their infection, from the neurodegenerative diseases such Alzheimer's disease to cancer.
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