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Deciphering the molecular mechanisms of epitranscriptome regulation in cancer

Seung Hun Han1, Junho Choe1

  • 1Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 04763; Research Institute for Natural Sciences, Hanyang University, Seoul 04763; Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul 04763, Korea.

BMB Reports
|December 10, 2020
PubMed

Insights

Chemical RNA modifications, known as the epitranscriptome, regulate gene expression and are linked to cancer development. Dysregulation of these modifications can lead to tumorigenesis, with varying cellular outcomes.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cancer Research

Background:

  • Post-transcriptional regulation is vital for cellular functions and fate.
  • Chemical RNA modifications, the epitranscriptome, are increasingly recognized for their regulatory roles.
  • Over 170 RNA modifications have been identified across various RNA types.

Purpose of the Study:

  • To review the mechanisms of cancer development linked to RNA modifications.
  • To highlight the role of the epitranscriptome in tumorigenesis.
  • To discuss the dual roles of RNA modifications in cancer.

Main Methods:

  • Literature review of recent studies on RNA modifications and cancer.
  • Analysis of the roles of 'writers,' 'readers,' and 'erasers' in RNA modification.
  • Examination of specific RNA modifications and their impact on cancer development.

Main Results:

  • Dysregulation of RNA modifications is closely associated with cancer.
  • Specific RNA modifications can have opposing effects on cellular processes.
  • The epitranscriptome presents complex mechanisms in cancer biology.

Conclusions:

  • RNA modifications are critical players in cancer development.
  • Understanding the epitranscriptome is crucial for cancer research.
  • Further investigation into RNA modification mechanisms is warranted for therapeutic strategies.

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