Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

81
Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
81
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

134
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
134
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

97
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
97
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

256
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
256
Papillary Dermis01:11

Papillary Dermis

5.0K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
5.0K
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

363
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
363

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic features of clonal hematopoiesis-associated genes in primary and CAR T-cell-related secondary T-cell malignancies.

Blood neoplasia·2026
Same author

Clinical, morphological, and genomic features of FGFR fusion Spitz neoplasms.

Pathology·2026
Same author

ERBB fusions in Spitz neoplasms, expanding the spectrum of Spitz-associated genomic fusions.

Pathology·2026
Same author

Clinical Outcomes and Prognostication of CRTC1::TRIM11 Fusion Cutaneous Tumors.

The American journal of surgical pathology·2026
Same author

Secondary T-cell lymphomas after chimeric antigen receptor T-cell therapy in dermatology.

Journal of the American Academy of Dermatology·2026
Same author

Cutaneous T-cell lymphoma tumors undergoing radiotherapy demonstrate immune shifts from malignant inflammation to wound healing and suggest markers of treatment durability.

Journal of the American Academy of Dermatology·2026
Same journal

Herpetic Whitlow in Association With a Cutaneous Infiltrate of Chronic Lymphocytic Leukemia.

The American Journal of dermatopathology·2026
Same journal

Basal Cell Carcinosarcoma with an Osteosarcomatous Component: A Case Report Supporting the Diagnostic Utility of SATB2 and TRAP Immunostaining with a Literature Review of 22 Cases.

The American Journal of dermatopathology·2026
Same journal

Demonstration of 23-Gene Expression Profile Test Utility Within PRAME Immunohistochemistry Results: A Case Series.

The American Journal of dermatopathology·2026
Same journal

On the Progression From Early-to Late-Stage Melanoma: A Potential Sequence of Molecular Events Using Data From Droplet Digital PCR and Array Comparative Genomic Hybridization, A Pilot Study.

The American Journal of dermatopathology·2026
Same journal

Montgomery Tubercles in the Male Areola: Histological Observations and a Brief About Past Investigators.

The American Journal of dermatopathology·2026
Same journal

Metastatic Syringocystadenocarcinoma Papilliferum Mimicking Cutaneous Squamous Cell Carcinoma of Unknown Primary in a Young Patient.

The American Journal of dermatopathology·2026
See all related articles

Related Experiment Video

Updated: Nov 26, 2025

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
06:36

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

Published on: May 1, 2019

7.3K

Vulvar Elastosis: A Novel Diagnostic Entity.

Sharlene Helene C See1, Timothy L Tan2, Traci A Kurtzer3

  • 1Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL.

The American Journal of Dermatopathology
|December 10, 2020
PubMed
Summary
This summary is machine-generated.

Vulvar elastosis, histopathologic changes in elastic fibers, is a novel finding in sun-protected skin. It is more common in older women and may be linked to aging or hormonal shifts.

More Related Videos

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.6K
Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

10.2K

Related Experiment Videos

Last Updated: Nov 26, 2025

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
06:36

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

Published on: May 1, 2019

7.3K
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.6K
Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

10.2K

Area of Science:

  • Dermatopathology
  • Gynecologic Pathology

Background:

  • Histopathologic abnormalities of elastic fibers, similar to solar elastosis, have been observed in vulvar biopsies.
  • These changes involve thick, curled, and irregular pale grey fibers in the dermis, sometimes resembling nodular solar elastosis in severe cases.

Purpose of the Study:

  • To define and characterize the changes of vulvar elastosis.
  • To evaluate the prevalence and clinical presentation of vulvar elastosis.

Main Methods:

  • Retrospective review of 238 vulvar biopsies.
  • Histopathologic analysis to identify and grade vulvar elastosis.
  • Correlation of elastosis findings with patient age and clinical presentation.

Main Results:

  • Vulvar elastosis was identified in 107 (45%) of the biopsies.
  • Patients with vulvar elastosis were significantly older (mean age 65) compared to those without (mean age 44).
  • A moderate correlation was found between age and the severity of vulvar elastosis (correlation coefficient = 0.55).

Conclusions:

  • Vulvar elastosis is a distinct diagnostic entity found in a sun-protected area.
  • The condition is more prevalent in women aged 45 and older.
  • Its pathogenesis is likely degenerative, potentially related to aging and/or hormonal changes.