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Published on: May 3, 2017
Cerebrospinal fluid glutamate changes in functional movement disorders
Benedetta Demartini1,2,3, Roberto William Invernizzi4, Laura Campiglio2
1Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy.
Abstract:
The aim of this study was to assess cerebrospinal fluid (CSF) concentrations of specific amino acids using a high-performance liquid chromatography system in a sample of patients with functional movement disorders (FMDs) and in a sample of controls. CSF levels of glutamate were significantly lower in patients with FMD than in controls. This finding argues in favor of glutamatergic dysfunction in the pathophysiology of FMD.
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