Related Experiment Video
Updated: Nov 26, 2025

Remote Laboratory Management: Respiratory Virus Diagnostics
Published on: April 6, 2019
Paediatric morbidity and mortality in Sierra Leone. Have things changed after the 2014/2015 Ebola outbreak?
Tom Sesay1, Olga Denisiuk2, Rony Zachariah3
1Child Health and Immunization Programme, Ministry of Health and Sanitation, Freetown, Sierra Leone.
Insights
The Ebola outbreak impacted Sierra Leone
Area of Science:
- Public Health
- Epidemiology
- Pediatric Medicine
Background:
- The 2014/2015 Ebola outbreak severely impacted Sierra Leone's health system, with potential long-term effects on child health.
- Assessing under-five morbidity and mortality trends for key childhood illnesses before, during, and after the Ebola epidemic is crucial for understanding health system recovery.
Purpose of the Study:
- To evaluate trends in under-five morbidity and mortality for malaria, acute respiratory infections (ARI)/pneumonia, watery diarrhea, and measles in Sierra Leone.
- To compare these trends between the pre-Ebola, during-Ebola, and post-Ebola periods to assess health system resilience and recovery.
Main Methods:
- Retrospective cross-sectional study utilizing District Health Information system (DHIS2) program data.
- Inclusion of under-five children from 1,250 health facilities across all 14 districts in Sierra Leone.
- Analysis of data from three distinct periods: pre-Ebola (June 2013-April 2014), during Ebola (June 2014-April 2015), and post-Ebola (June 2016-April 2017).
Main Results:
- Consultations for malaria, ARI/pneumonia, and diarrhea decreased during Ebola but returned to pre-Ebola levels post-outbreak.
- Significant reduction in case-fatality rates for malaria, ARI/pneumonia, and diarrhea in the post-Ebola period compared to the pre-Ebola period (P<0.0001).
- A 12-fold increase in monthly measles cases was observed in the post-Ebola period compared to the pre-Ebola period; case-fatality post-Ebola was significantly lower than during Ebola (P<0.0001).
Conclusions:
- Under-five child consultations at Sierra Leonean health facilities have recovered to pre-Ebola levels.
- Case-fatality rates for common childhood illnesses have significantly decreased, indicating improved health outcomes.
- The substantial rise in measles cases post-Ebola highlights critical gaps in immunization coverage requiring targeted interventions.
Abstract:
Background: Sierra Leone was severely affected by the 2014/2015 Ebola outbreak which is likely to have had longer term repercussions on the health system including on paediatric morbidity and mortality. We thus assessed under-five morbidity and mortality for malaria, acute respiratory Infections (ARI)/pneumonia, watery diarrhoea and measles during the post-Ebola period in Sierra Leone and compared this with the pre- and intra-Ebola periods. Methods: This was a retrospective cross-sectional study using program data from the District Health Information system (DHIS2) and sourced from 14 districts in Sierra Leone. It included under-five children from 1,250 health facilities country-wide. Study periods included: before (June 1 st, 2013-April 30 th, 2014); during (June 1 st, 2014-April 30 th, 2015); and after Ebola (June 1 st, 2016-April 30 th, 2017). Results: Malaria, ARI/pneumonia and diarrhoea consultations declined during Ebola but recovered to pre-Ebola levels in the post-Ebola period. During the post-Ebola period, there was a highly significant reduction in case-fatality for the first three morbidities compared to the pre-Ebola period ( P<0.0001). Average number of measles cases increased from 48/month in the pre-Ebola period to 568/month (12-fold increase) post-Ebola. Although there was no difference in measles case-fatality between the pre- and post-Ebola periods, case-fatality post-Ebola was significantly lower than during Ebola (Relative Risk: 0.05, 95% confidence interval 0.02-0.15, P<0.0001). Conclusions: Consultations for under-five children at health facilities in Sierra Leone recovered to pre-Ebola levels and case-fatality for common childhood illnesses declined significantly. This is a change for the better. However, the high level of reported measles cases in the post-Ebola period indicates gaps in immune status and needs focused attention.
More Related Videos
10:57Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
Published on: August 22, 2012
10:11Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
Published on: September 27, 2014
Related Concept Videos
Pharmacokinetics in Pediatric Patients: Drug Excretion
Pharmacokinetics in Pediatric Patients: Drug Distribution
Drug Dosing: Infants and Children
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Immunodeficiency Diseases
There are three main causes of immunodeficiency...