Related Experiment Video
Updated: Nov 26, 2025
Mechanical Testing of Mouse Carotid Arteries: from Newborn to Adult
Published on: February 23, 2012
The effect of Celiac disease on cardiac functions and aortic elasticity parameters in children
Fatos Alkan1, Guzide Dogan2, Erhun Kasırga3
1Celal Bayar University, School of Medicine, Division of Pediatric Cardiology, Department of Pediatrics, Manisa, Turkey.
Insights
Celiac disease impacts myocardial functions in children, affecting both systole and diastole. Routine cardiac evaluations are recommended for early detection of potential cardiac issues in celiac patients.
Area of Science:
- Pediatric Cardiology
- Gastroenterology
- Cardiovascular Research
Background:
- Celiac disease is an autoimmune disorder affecting the small intestine.
- Potential extra-intestinal manifestations, including cardiac involvement, are increasingly recognized.
Purpose of the Study:
- To assess the impact of Celiac disease on myocardial functions.
- To evaluate aortic elasticity parameters in children with Celiac disease.
Main Methods:
- Comparative study involving 30 children with Celiac disease and 30 healthy controls.
- Cardiac function assessment using conventional transthoracic echocardiography and tissue Doppler imaging.
- Aortic elasticity parameters (strain, distensibility, stiffness index) measured via M-mode echocardiography.
Main Results:
- No significant differences in standard echocardiographic parameters (E/A ratio, wave velocities) between groups.
- Statistically significant differences observed in isovolumetric relaxation time, isovolumetric contraction time, and myocardial performance index.
- No significant differences in aortic strain, distensibility, or stiffness index.
Conclusions:
- Celiac disease affects myocardial functions during systole and diastole in children.
- Routine cardiac evaluation may be beneficial for early detection of cardiac affection in celiac patients.
Aim:
We aimed to investigate the effect of Celiac disease on myocardial functions and aortic elasticity parameters.
Materials And Methods:
Thirty children with Celiac disease and 30 healthy children were enrolled in the study. Both the groups were similar in terms of age and gender. Cardiac functions of all children in the patients and control group were evaluated using conventional transthoracic echocardiography and tissue Doppler imaging. Aortic strain, distensibility, and stiffness index were calculated by M-mode echocardiography.
Results:
The demographic findings, height, weight, and body mass index of cases were similar among two groups. No statistical difference was found between E wave velocity for conventional transthoracic echocardiography and tissue Doppler imaging measurements of the mitral valve; early diastolic flow peak velocity, A wave velocity; late diastolic flow peak velocity; and E/A ratio. Isovolumetric relaxation time and isovolumetric contraction time ratios were statistically different between the groups (p = 0.000, p = 0.000, p = 0.000). The myocardial performance index calculated according to the pulse Doppler measurement results was found to be statistically different between the groups (p = 0.000). There was no statistical difference between the groups in terms of aortic strain, distensibility, and stiffness index.
Conclusion:
In this study, both conventional transthoracic echocardiography and tissue Doppler imaging revealed the affection of the myocardial functions during systole and diastole in children with Celiac disease. Therefore, early follow-up and routine cardiac evaluation of celiac patients may be appropriate due to the increased risk of cardiac affection.
More Related Videos
Related Concept Videos
01:30Coronary Artery Disease I: Introduction
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests