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Lactococcus lactis and Resveratrol Decrease Body Weight and Increase Benefic Gastrointestinal Microbiota in Mice.

Keila Lopes Mendes1, Deborah de Farias Lelis1, Letícia Antunes Athayde Souza1

  • 1Laboratory of Health Science, Postgraduate Program in Health Science, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.

Protein and Peptide Letters
|December 11, 2020
PubMed
Summary
This summary is machine-generated.

Resveratrol combined with the probiotic Lactococcus lactis reduced body weight and modulated gut bacteria in mice. This combination showed potential for managing metabolic health by influencing the gut microbiome.

Keywords:
Probioticimmune systemmicrobiome modulation.phenolicsecretory IgAsynergismweight reduction

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Area of Science:

  • Microbiology
  • Nutrition Science
  • Gastroenterology

Background:

  • The gut microbiome plays a crucial role in maintaining overall health and homeostasis.
  • Microbiota dysbiosis is linked to metabolic disorders, highlighting the need for microbiome-modulating compounds.
  • Resveratrol, a natural compound from grapes, shows promise for microbiome modulation.

Purpose of the Study:

  • To investigate the synergistic effects of resveratrol and the probiotic Lactococcus lactis on gut microbiota composition.
  • To assess the impact of this combination on body weight in a mouse model.

Main Methods:

  • Female mice were divided into four groups receiving standard diet, standard diet with Lactococcus lactis, standard diet with resveratrol, or standard diet with both.
  • Gastrointestinal samples, blood, and mucus were collected for analysis.
  • Levels of Immunoglobulin A (IgA), Immunoglobulin E (IgE), Lac+ and Lac- bacteria, and Lactobacillus were quantified.

Main Results:

  • The combination of resveratrol and Lactococcus lactis significantly decreased body weight compared to control groups.
  • This synergistic treatment reduced the abundance of Lac- bacteria while increasing Lac+ bacteria.
  • Secretory IgA levels were lower in the combined treatment group compared to those receiving only probiotics or resveratrol.

Conclusions:

  • A potential synergistic effect was observed between resveratrol and Lactococcus lactis in modulating the stomach and intestinal microbiota.
  • This combination may offer a novel approach for managing metabolic health through gut microbiome manipulation.