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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Special Staining Techniques01:13

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Specialized staining techniques play a vital role in microbiology by enabling the visualization of specific bacterial structures that remain undetectable with standard microscopy methods. These techniques not only enhance the structural visualization of bacterial cells but also provide critical insights into their pathogenicity and classification. Additionally, they support diagnostic and research endeavors in microbiology by identifying key bacterial features.Capsule Staining for Virulence...
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Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

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Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
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Endocarditis I: Introduction01:25

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Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
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Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Staphylococcal Skin and Soft Tissue Infections.

Timothy J Hatlen1, Loren G Miller2

  • 1Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA; Division of HIV, Harbor-UCLA Medical Center, Torrance, CA, USA; Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA; David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Infectious Disease Clinics of North America
|December 11, 2020
PubMed
Summary

Staphylococcus aureus causes skin infections, and many strains are methicillin-resistant. Treatment for Staphylococcus aureus infections should cover methicillin-resistant strains, with therapy duration typically 5-7 days.

Keywords:
Acute bacterial skin and skin structure infectionsCellulitis with abscessPurulent cellulitisStaphylococcus aureus skin infectionSuppurative cellulitis

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Dermatology

Background:

  • Staphylococcus aureus is a primary cause of purulent skin and soft tissue infections.
  • A significant proportion of Staphylococcus aureus strains exhibit methicillin resistance, complicating treatment.
  • Empiric antibiotic therapy is crucial to cover potential methicillin-resistant Staphylococcus aureus (MRSA) infections.

Purpose of the Study:

  • To review the management of Staphylococcus aureus skin and soft tissue infections.
  • To emphasize the importance of considering methicillin resistance in empiric treatment strategies.
  • To outline factors influencing definitive antibiotic selection and expected treatment outcomes.

Main Methods:

  • Literature review of Staphylococcus aureus infections and antibiotic therapy.
  • Analysis of factors guiding antibiotic choice, including resistance patterns and clinical severity.
  • Evaluation of typical treatment durations and response expectations.

Main Results:

  • Bacterial wound cultures are essential for understanding local antibiotic susceptibility.
  • No single antibiotic has demonstrated superiority for definitive therapy.
  • Antibiotic selection depends on infection severity, local resistance, safety, tolerability, and cost.

Conclusions:

  • Empiric therapy for Staphylococcus aureus infections must account for methicillin resistance.
  • Definitive antibiotic choice is multifactorial, balancing efficacy with patient-specific factors.
  • A 5-to-7-day course of antibiotics is generally sufficient for treating these infections.