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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Gram-Negative Skin and Soft Tissue Infections.

Jean-Francois Jabbour1, Souha S Kanj1

  • 1Division of Infectious Diseases, Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon.

Infectious Disease Clinics of North America
|December 11, 2020
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Summary

Gram-negative bacilli (GNB) are an increasing cause of skin and soft tissue infections (SSTIs). This review covers GNB in SSTIs, focusing on epidemiology, risk factors, outcomes, and management strategies, including novel antibiotics.

Keywords:
DiagnosisEpidemiologyGram-negativeSkin and soft tissue infectionsTreatment

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Area of Science:

  • Infectious Diseases
  • Microbiology
  • Dermatology

Background:

  • Gram-negative bacilli (GNB) are an underappreciated cause of skin and soft tissue infections (SSTIs).
  • The incidence of GNB-SSTIs is rising, exacerbated by increasing antimicrobial resistance.
  • Clinical diagnosis of SSTIs is common, but rapid diagnostics can improve treatment initiation and patient outcomes.

Purpose of the Study:

  • To review the role of GNB in SSTIs.
  • To summarize the epidemiology, risk factors, and outcomes associated with GNB-SSTIs.
  • To discuss current and novel therapeutic strategies for managing GNB-SSTIs.

Main Methods:

  • Literature review of GNB in skin and soft tissue infections.
  • Analysis of epidemiological data and risk factors.
  • Summary of clinical management and antibiotic options.

Main Results:

  • GNB are a growing concern in SSTI etiology.
  • Antimicrobial resistance is a significant challenge in treating GNB-SSTIs.
  • Rapid diagnostics and novel antibiotics show promise for improved management.

Conclusions:

  • GNB represent a significant and increasing threat in SSTIs.
  • Effective management requires understanding epidemiology, risk factors, and treatment options.
  • Novel antibiotics and diagnostics are crucial for combating GNB-SSTIs.