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Crystal Growth: Principles of Crystallization

Crystal Growth: Principles of Crystallization

Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...

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Author Spotlight: High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography

Author Spotlight: High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography

Published on: March 10, 2023

Screening cells for crystals: a synergistic approach.

Terese Bergfors¹, Soneya Majumdar¹

¹Department of Cell and Molecular Biology, Uppsala University, Sweden.

Journal of Applied Crystallography

|December 11, 2020

Summary

Researchers developed a fast and sensitive method for screening crystals within cells. This new technique enhances structural biology research capabilities.

Area of Science:

Structural Biology
Crystallography

Background:

Structural biology relies on determining crystal structures.
In-cell crystallography methods are crucial for understanding biological molecules in their native environment.

Purpose of the Study:

To introduce a rapid and sensitive method for screening crystals in cellulo.
To provide a valuable new tool for structural biologists.

Main Methods:

The study reports a novel screening approach for in-cell crystallography.
Details of the rapid and sensitive method are presented.

Main Results:

A successful rapid and sensitive method for in-cell crystal screening was developed.
The method proved effective in identifying crystals within cellular environments.

Keywords:

X-ray powder diffraction in cellulo crystallization in vivo crystals small-angle X-ray scattering

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Conclusions:

The reported method is a significant advancement for structural biology.
This technique offers a valuable addition to the existing toolbox for in-cell structural studies.